Scientific Institute for Natural Neurostimulation
Pioneering Neurostimulation Research
Child development
Child Cognitive Development with the Maternal Heartbeat: A Mother-Fetus Neurocognitive Model and Architecture for Bioengineering Systems
The theoretical article aims to conceptualize the Mother-fetus Neurocognitive (MFNC) model. It reviews recent studies on shared intentionality to establish the first step in studying the MFNC model. This advanced Neurocognitive model describes evolving cognition from the pre-perceptual communication in the Mother-fetus ecological system due to nonlocal neuronal coupling. The study highlights the core principles of the MFNC model. This knowledge can enhance our understanding of the beginning of cognition and enable the development of various applications, including assessing cognition in preverbal children and developing noninvasive brain-computer interaction. Springer 2024.
Recent articles:
–Val Danilov, I. (2023). Shared Intentionality Before Birth: Emulating a Model of Mother-Fetus Communication for Developing Human-Machine Systems. In: Arai, K. (eds) Intelligent Systems and Applications. IntelliSys 2023. Lecture Notes in Networks and Systems, vol 824. Springer, Cham.
–Val Danilov I. (2023). Low-Frequency Oscillations for Nonlocal Neuronal Coupling in Shared Intentionality Before and After Birth: Toward the Origin of Perception. OBM Neurobiology 2023; 7(4): 192; doi:10.21926/obm.neurobiol.2304192.
–Val Danilov I, Svajyan A, Mihailova S. (2023). A New Computer-Aided Method for Assessing Children's Cognition in Bioengineering Systems for Diagnosing Developmental Delay. OBM Neurobiology 2023; 7(4): 189; doi:10.21926/obm.neurobiol.2304189.
–Val Danilov, I. (2023). Advances in Computer-Aided Diagnosis of Developmental Delay in Children Using Bioengineering Systems: A New Math Model and Algorithm. In: Rajakumar, G., Du, KL., Rocha, Á. (eds) Intelligent Communication Technologies and Virtual Mobile Networks. ICICV 2023. Lecture Notes on Data Engineering and Communications Technologies, vol 171. pp. 443-458. Springer, Singapore. https://doi.org/10.1007/978-981-99-1767-9_33
–Val Danilov, Igor. (2022). A Bioengineering System for Assessing Children's Cognitive Development by Computerized Evaluation of Shared Intentionality. Proceedings of the 2022 International Conference on Computational Science and Computational Intelligence (CSCI'22: December 14-16, 2022, Las Vegas, Nevada, USA); Publisher: IEEE Computer Society, Editors: Hamid R. Arabnia, Leonidas Deligiannidis, Fernando G. Tinetti, and Quoc-Nam Tran. ISBN-13: 979-8-3503-2028-2; IEEE Catalog Number: CFP2271X-USB, doi: 10.1109/CSCI58124.2022.00323. pp:1591-1598.
Chronic pain
Acoustic photonic intellectual neurostimulation (APIN) in dysmenorrhea management: a case study on an adolescent.
The majority (70-93%) of adolescents have discomfort associated with menstruation. The main symptom of dysmenorrhea is pain concentrated in the lower abdomen or pelvis and may radiate to the thighs and lower back. Recent research identified risk factors of dysmenorrhea: nine physiological factors and three psychological ones: distress, depression, and anxiety. According to IASP, pain is always a subjective experience that is influenced to varying degrees by biological, psychological, and social factors; the experience of pain cannot be reduced to activity in sensory pathways. Insofar as these arguments are correct, the menstrual pain is partly associated with the aware psychological state. Awareness refers to mental processes, such as perceiving and remembering, related to neuronal activity, in the frontal and parietal brain areas. This novel neuromodulation technique–the acoustic photonic intellectual neurostimulation (APIN)–exerts its function through three therapeutic agents which cooperatively stimulate synaptic activity in specific neuronal networks of the frontal and parietal regions of the brain. The APIN exerts its weak impact not on the whole noted areas but on specific neuronal circuits of these brain areas to treat pain and brain disorders, such as distress, depression, and anxiety, that are associated with aware psychological states. We conducted a case study with a woman 16 years old. Since age 14, when the menstrual cycle began, it was accompanied by dysmenorrhea: acute pain in the lower abdomen (10 points out of 10). A warm compress on the lower abdomen reduces pain. The APIN course consisted of 10 sessions of 20-minute exercises. The outcome was menstrual pain relief down to 1 point.Brain Stimulation 2025
Recent articles:
–Val Danilov, I., Medne, D., & Mihailova, S. (2025). Modulating neuroplasticity with acoustic photonic intellectual neurostimulation (APIN): a case study on neurodegenerative disorder. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 18(1), 561.
–Medne, D., Val Danilov, I., & Mihailova, S. (2025). The effect of acoustic and photonic intervention combined with mental load on chronic headaches: a case study. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 18(1), 542-543.
–Val Danilov I. (2024). The Origin of Natural Neurostimulation: A Narrative Review of Noninvasive Brain Stimulation Techniques. OBM Neurobiology 2024; 8(4): 260; doi:10.21926/obm.neurobiol.2404260.
Aging
The Origin of Social Skills: Manipulating Shared Intentionality in Bioengineering Systems for Empathy Training.
This pilot study (N = 28) aims to develop universal computer-aided empathy training. The experiment tests a research design of manipulating behavior in subjects toward non-affective cues in a bioengineering system. The study implements the Mother-Fetus Neurocognitive Model to involve subjects in subliminal cognitive collaboration with confederates, which enables subjects to associate the meaning of empathy with the picture only seen by confederates. The outcome shows the feasibility of the chosen research design with the efficiency of the 7-minute training: 50% of subjects confidentially attribute an empathic attitude to the neutral stimuli, and the probability of such an outcome, in a case if achieved by chance, is only p = 0.004. Since subliminal collaboration in adults benefits from the innate quality of shared intentionality, the paper also discusses the genesis of basic emotions and social skills through neuronal coordinated activity in the mother-child dyad beginning from the pregnancy period. OBM Neurobiology 2024.
Recent articles:
–Val Danilov, I., Mihailova, S. (2024). An Algorithm for the Computer-Aided Method of Empathy Training by Modulating Shared Intentionality. In: Ragavendiran, S.D.P., Pavaloaia, V.D., Mekala, M.S., Cabezuelo, A.S. (eds) Innovations and Advances in Cognitive Systems. ICIACS 2024. Information Systems Engineering and Management, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-031-69201-7_3
–Val Danilov I, Mihailova S. (2023). Empirical Evidence of Shared Intentionality: Towards Bioengineering Systems Development. OBM Neurobiology 2023; 7(2): 167; doi:10.21926/obm.neurobiol.2302167.
Future
Shared Intentionality Modulation at the Cell Level: Low-Frequency Oscillations for Temporal Coordination in Bioengineering Systems.
The theoretical article aims to develop knowledge about the modulation of shared intentionality at the cellular level. A hypothesis about the neurobiological processes during shared intentionality argues that this pre-perceptual communication occurs through nonlocal neuronal coupling in an ecosystem that can be described as the mother-fetus communication model. The current theoretical study analyses literature to discuss recent findings on the effect of oscillations on neuronal temporal coordination to verify whether external low-frequency oscillations can only synchronize specific local neuronal networks from peripheral and central nervous subsystems for modulating shared intentionality. The review discusses 4 findings. First, gamma oscillations are associated with the temporal coordination of local ensembles of cells. Second, there is a relationship between low-frequency brain oscillations and the temporal coordination of peripheral and central nervous subsystems. Third, delta oscillations influence neuronal activity by modulating gamma activity. Fourth, external delta and gamma oscillations increase cortical excitability. The article concludes that delta oscillations can modulate gamma oscillations in the different subsystems of the nervous system, providing temporal network coordination. An external low-frequency oscillator can coordinate only relevant local neuronal networks in various subsystems already exhibiting gamma activity. OBM Neurobiology 2023
Recent articles:
–Val Danilov I. (2023). Theoretical Grounds of Shared Intentionality for Neuroscience in Developing Bioengineering Systems. OBM Neurobiology 2023; 7(1): 156; doi:10.21926/obm.neurobiol.2301156.